Roma bring Diego Perotti and Stephan El Shaarawy back to the starting XI with Mohamed Salah, seeking a sixth consecutive victory at Empoli.
It kicks off at 17.00 GMT, follow all the build-up and action as it happens on our Liveblog from 16.30 GMT.
The Giallorossi have won five on the bounce in Serie A to climb back into the race for a Champions League spot.
Empoli, on the other hand, have stuttered recently and are winless in seven rounds.
Roma bring Diego Perotti and Stephan El Shaarawy back to the starting XI with Mohamed Salah, seeking a sixth consecutive victory at Empoli.
It kicks off at 17.00 GMT, follow all the build-up and action as it happens on our Liveblog from 16.30 GMT.
The Giallorossi have won five on the bounce in Serie A to climb back into the race for a Champions League spot.
Empoli, on the other hand, have stuttered recently and are winless in seven rounds.
This will be an even tougher test than usual for Marco Giampaolo, as he has to do without suspended stars Riccardo Saponara and Lorenzo Tonelli.
That means Uros Cosic starts in defence with Rade Krunic supporting strikers Massimo Maccarone and Manuel Pucciarelli.
It’s a very special game for Roma loaners Leandro Paredes and Lukasz Skorupski.
Roma are missing Daniele De Rossi and Norbert Gyomber, but Francesco Totti is available again on the bench after his row with Coach Luciano Spalletti.
Perotti and El Shaarawy return to the starting XI with Salah, while Seydou Keita steps in to midfield.
Edin Dzeko is ruled out after coming down with flu symptoms.
Last week in the 5-0 demolition of Palermo he made headlines for both bagging a brace and managing the worst miss of the season.
Kevin Strootman was tipped for a start, but it has been raining heavily in Tuscany all day, so the state of the pitch prompts a more cautious response.
Empoli have not beaten Roma, home and away in all competition, since a 1-0 result in February 2007.
That was followed by two stalemates and four defeats between Serie A and the Coppa Italia.
Empoli: Skorupski; Laurini, Cosic, Ariaudo, Mario Rui; Zielinski, Paredes, Croce; Krunic; Maccarone, Pucciarelli
Empoli bench: Pugliesi, Pelagotti, Camporese, Zambelli, Bittante, Buchel, Maiello, Diousse, Mchedlidze, Piu, Livaja
Roma: Szczesny; Maicon, Rudiger, Zukanovic, Digne; Pjanic, Keita, Nainggolan; Salah, Perotti, El Shaarawy
Roma bench: De Sanctis, Lobont, Castan, Florenzi, Torosidis, Manolas, Emerson, Vainqueur, Strootman, Totti, Dzeko, Iago Falque