The pressure is on Serie A leaders Inter and they visit an Empoli side that has really impressed this season.
It kicks off at 17.00 GMT, follow all the action from every Serie A game on our LIVEBLOG.
The Nerazzurri ended 2015 with a shock 2-1 home defeat against Lazio, cutting the gap at the top of the table to a single point.
The pressure is on Serie A leaders Inter and they visit an Empoli side that has really impressed this season.
It kicks off at 17.00 GMT, follow all the action from every Serie A game on our LIVEBLOG.
The Nerazzurri ended 2015 with a shock 2-1 home defeat against Lazio, cutting the gap at the top of the table to a single point.
Felipe Melo was sent off in that game for an astounding kick on Lucas Biglia’s shoulder and therefore begins a three-match ban, but he is the only absentee for Coach Roberto Mancini.
Stevan Jovetic is benched in favour of Adem Ljajic and Geoffrey Kondogbia returns to midfield.
Empoli are without Lorenzo Tonelli and Levan Mchedlidze, but can count on sought-after trequartista Riccardo Saponara supporting Massimo Maccarone and Manuel Pucciarelli.
The quality of Piotr Zielinski and Leandro Paredes in midfield is also worth keeping an eye on, as the Tuscans have played some of the best football in Serie A this season.
Empoli have won their last four games, a club record in the top flight, but their history with Inter is frankly unimpressive.
They’ve lost eight of the last 11 meetings with Inter, home and away in all competition, with a single victory in April 2006.
Having said that, last season they played a 0-0 draw at the Castellani and were unlucky to lose 4-3 at San Siro.
Empoli: Skorupski; Laurini, Costa, Barba, Mario Rui; Zielinski, Paredes, Buchel; Saponara; Pucciarelli, Maccarone
Empoli bench: Pugliesi, Pelagotti, Zambelli, Bittante, Croce, Maiello, Diousse, Piu, Cosic, Camporese, Krunic, Livaja
Inter: Handanovic; D'Ambrosio, Miranda, Murillo, Nagatomo; Brozovic, Medel, Kondogbia, Perisic, Icardi, Ljajic
Inter bench: Carrizo, Juan Jesus, Palacio, Jovetic, Biabiany, Telles, Guarin, Montoya, Santon, Ranocchia, Gnoukouri, Manaj