Roma are forced into some big changes and Daniele De Rossi fails a fitness test, but Leo Messi starts for Barcelona.
It kicks off at 19.45 GMT, follow the build-up and action as it happens on our LIVEBLOG.
The Giallorossi are ravaged by injuries going into Camp Nou, as Mohamed Salah, Gervinho, Francesco Totti and Kevin Strootman are unavailable.
Roma are forced into some big changes and Daniele De Rossi fails a fitness test, but Leo Messi starts for Barcelona.
It kicks off at 19.45 GMT, follow the build-up and action as it happens on our LIVEBLOG.
The Giallorossi are ravaged by injuries going into Camp Nou, as Mohamed Salah, Gervinho, Francesco Totti and Kevin Strootman are unavailable.
De Rossi was set to be the captain, but he too failed a fitness test this evening and is only on the bench.
There was meant to be a change of tactics too, going to 4-1-4-1 with Seydou Keita in the holding role in front of the defence.
However, it’s 4-3-3 with Alessandro Florenzi moved into a more advanced role alongside Edin Dzeko and Iago Falque, allowing Douglas Maicon in at right-back.
Florenzi scored perhaps the goal of the season the last time these sides met, lobbing Marc-Andre Ter Stegen from the centre-circle.
He is up for the Puskas Award thanks to that moment of magic and the 1-1 draw means Barcelona have never beaten Roma in three Champions League encounters.
Barça are fresh from a 4-0 demolition job on Real Madrid in El Clasico and Messi made his comeback after two months, but here gets his first start since the knee ligament injury.
Javier Mascherano, Rafinha and Douglas are all unavailable for ex-Roma boss Luis Enrique, but Luis Suarez and Neymar are to be feared.
Andres Iniesta had a slight muscular problem after Real Madrid and is only on the bench.
Barcelona: Ter Stegen; Dani Alves, Piquè, Vermaelen, Jordi Alba; Sergi Roberto, Busquets, Rakitic; Messi, Suarez, Neymar
Barcelona bench: Bravo, Bartra, Adriano, Mathieu, Iniesta, Munir, Samper
Roma: Szczesny; Maicon, Manolas, Rudiger, Digne; Pjanic, Keita, Nainggolan; Florenzi, Dzeko, Iago Falque
Roma bench: De Sanctis, Castan, Torosidis, Vainqueur, De Rossi, Iturbe, Ucan