Milan have a mountain to climb if they want to stay in the Europa League, so look to Andre Silva and Patrick Cutrone against Arsenal.
It kicks off at 20.05 GMT and the first leg ended 2-0 for the Gunners at San Siro.
Follow all the build-up and action as it happens on the LIVEBLOG.
Milan have a mountain to climb if they want to stay in the Europa League, so look to Andre Silva and Patrick Cutrone against Arsenal.
It kicks off at 20.05 GMT and the first leg ended 2-0 for the Gunners at San Siro.
Follow all the build-up and action as it happens on the LIVEBLOG.
The Rossoneri had been unbeaten in 13 competitive games until that home defeat, but resumed their journey last weekend with a last-gasp 1-0 victory away to Genoa.
It was earned by Andre Silva’s header, his debut Serie A goal, and the Portugal international is rewarded with a starting spot in the new 4-4-2 formation, partnering Cutrone.
The young pair of forwards scored 10 goals between them in the Europa League group phase.
Hakan Calhanoglu and Suso move to wider roles, with Lucas Biglia rested, but Fabio Borini has to play at right-back because Davide Calabria and Ignazio Abate are out of action, with Luca Antonelli not fully fit either.
Arsenal are without Alexandre Lacazette and Santi Cazorla still, while ex-Milan forward Pierre-Emerick Aubameyang is cup-tied.
Hector Bellerin and Nacho Monreal are back in the squad for Arsene Wenger, who was still trying to win back the fans mounting their Wenger Out campaign.
Jack Wilshere is surprisingly chosen to support Danny Welbeck, with Mesut Ozil and Henrikh Mkhitaryan in wider roles.
Arsenal: Ospina; Bellerin, Koscielny, Mustafi, Monreal; Ozil, Ramsey, Xhaka, Mkhitaryan; Wilshere; Welbeck
Arsenal bench: Cech, Chambers, Maitland-Niles, Kolasinac, Elneny, Iwobi, Nketiah
Milan: G Donnarumma; Borini, Bonucci, Romagnoli, Rodriguez; Suso, Kessie, Montolivo, Calhanoglu; Andre Silva, Cutrone
Milan bench: Storari, Zapata, Musacchio, Locatelli, Biglia, Bonaventura, Kalinic
Ref: Eriksson (SWE)
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