Giacomo Bonaventura and Moise Kean make their returns to the Italy starting XI against Malta, ending an absence of three and two years respectively.
It kicks off at the Stadio San Nicola in Bari at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
There have been numerous injury problems leading up to this game and Tuesdayโs trip to Wembley Stadium against England, so Luciano Spalletti had to cast the net a little wider for his talent.
Juventus striker Kean gets his first start for Italy since the 5-0 win over Lithuania, a World Cup qualifier in September 2021.
He found the net twice that day and has four goals in as many starts for the Azzurri at senior level.
As for Bonaventura, the Fiorentina midfielder has not represented Italy since the 6-0 friendly win over Moldova on October 7, 2020.
He had not even featured in a competitive match for the Azzurri since the 1-0 Nations League defeat to Portugal in September 2018.