Stephan El Shaarawy, Alessandro Florenzi and Graziano Pellè are expected to start for Italy in a 3-4-3 formation against Spain.
The Azzurri host the reigning European Champions at the Dacia Arena in Udine on Thursday.
This international friendly will kick off at 19.45 GMT.
Several players have already pulled out due to injury, including Marco Verratti, Andrea Barzagli, Giorgio Chiellini and Claudio Marchisio.
Andrea Pirlo and Sebastian Giovinco were not called up, as the MLS season has only just got started.
Stephan El Shaarawy, Alessandro Florenzi and Graziano Pellè are expected to start for Italy in a 3-4-3 formation against Spain.
The Azzurri host the reigning European Champions at the Dacia Arena in Udine on Thursday.
This international friendly will kick off at 19.45 GMT.
Several players have already pulled out due to injury, including Marco Verratti, Andrea Barzagli, Giorgio Chiellini and Claudio Marchisio.
Andrea Pirlo and Sebastian Giovinco were not called up, as the MLS season has only just got started.
Coach Antonio Conte tested out a new 3-4-3 formation today in training and Rai Sport believe the starting trident will be Roma’s El Shaarawy, Lazio figure Antonio Candreva and Southampton striker Pellè.
Alessandro Florenzi and Emanuele Giaccherini will be on the wings, surrounding Marco Parolo and Riccardo Montolivo.
Due to the shortage of centre-backs, Matteo Darmian will be re-routed into the defensive three with Leonardo Bonucci and Francesco Acerbi.
Gigi Buffon should be cleared to play despite suffering from flu symptoms over the last couple of days.
Italy (probable): Buffon; Darmian, Bonucci, Acerbi; Giaccherini, Parolo, Montolivo, Florenzi, El Shaarawy, Pellè, Candreva