Juventus are expected to use a versatile line-up with Juan Cuadrado, Paulo Dybala and Cristiano Ronaldo against Manchester United.
It kicks off tonight at 19.45 UK time (18.45 GMT) at Old Trafford.
The Bianconeri are forced to do without injured Mario Mandzukic, Sami Khedira, Emre Can and Leonardo Spinazzola.
Douglas Costa is not 100 per cent fit after a lay-off and looked rusty in Saturday’s 1-1 draw with Genoa.
Juventus are expected to use a versatile line-up with Juan Cuadrado, Paulo Dybala and Cristiano Ronaldo against Manchester United.
It kicks off tonight at 19.45 UK time (18.45 GMT) at Old Trafford.
The Bianconeri are forced to do without injured Mario Mandzukic, Sami Khedira, Emre Can and Leonardo Spinazzola.
Douglas Costa is not 100 per cent fit after a lay-off and looked rusty in Saturday’s 1-1 draw with Genoa.
It’s reported Max Allegri was unsure between a 3-5-2 and a 4-4-2, but his final line-up may well be a combination of the two systems.
Alex Sandro and Joao Cancelo can push up in turns, with Cuadrado able to come back and help the midfield when needed.
Dybala and Ronaldo can also rotate their roles as the main centre-forward.
Manchester United are missing Marouane Fellaini, Alexis Sanchez, Jesse Lingard, Phil Jones, Diogo Dalot and Scott McTominay, while Marcos Rojo and Antonio Valencia are not 100 per cent fit.
Anthony Martial is expected to get the nod with Romelu Lukaku and Marcus Rashford, while Paul Pogba faces his old club alongside Nemanja Matic and Fred.
Probable line-ups
Manchester United: De Gea; Young, Smalling, Bailly, Shaw; Fred, Matic, Pogba; Rashford, Lukaku, Martial
Juventus: Szczesny; Cancelo, Bonucci, Chiellini, Alex Sandro; Bentancur, Pjanic, Matuidi; Cuadrado, Dybala, Ronaldo