Napoli star Khvicha Kvaratskhelia could rest against Rangers tonight with Giovanni Simeone and Giacomo Raspadori starting in attack for the Partenopei.
It kicks off at 20.00 UK time.
Napoli have already qualified for the Champions League Round of 16 with two games to spare, but need a victory to boost their chances to win the group.
Amir Rrahmani and Salvatore Sirigu are injured and Luciano Spalletti will rest some of his regular starters at the Stadio Maradona tonight.
Kim, Piotr Zielinski and Victor Osimhen are expected to go on the bench and the same is true of Kvaratskhelia. Raspadori is favourite to start over the Georgia international on the left flank with Simeone playing as a centre forward.
Napoli are the only unbeaten team in Serie A this season and have the most prolific attack in Italy’s top flight and in the Champions League.
Champions League, Napoli-Rangers: probable line-ups
Napoli (4-3-3): Meret; Di Lorenzo, Ostigard, Juan Jesus, Mario Rui; Ndombele, Lobotka, Elmas; Politano, Simeone, Raspadori.
Rangers (3-4-3): McGregor; Lundstram, King, Davies: Tavernier, Jack, Davis, Barisic; Arfield, Colak, Kent.