Juventus stick with Teun Koopmeiners, Nico Gonzalez and Dusan Vlahovic, while Napoli give Scott McTominay his first start behind Romelu Lukaku and Khvicha Kvaratskhelia.
It kicks off at the Allianz Juventus Stadium at 17.00 UK time (16.00 GMT).
The Bianconeri drew their last two Serie A matches 0-0 against Roma and Empoli, but are fresh off a Champions League 3-1 victory over PSV Eindhoven.
Thiago Motta sticks to almost the same starting XI, including Weston McKennie in midfield, plus Nico Gonzalez, Koopmeiners and Kenan Yildiz supporting Vlahovic.
The only concern was for Federico Gatti, who is not at 100 per cent, while Arkadiusz Milik and Francisco Conceicao are injured.
Pierre Kalulu therefore moves into central defence, with Nicolo’ Savona at right-back.
Napoli had a disastrous start to their season losing 3-0 at Verona, but have since kicked into gear with three consecutive victories over Bologna, Parma and Cagliari.
This is a special match for former Juventus player and coach Antonio Conte, who returns to Turin as an opponent.
Lukaku has hit the ground running at Napoli, but the big change is the first start for former Manchester United midfielder McTominay, with Billy Gilmour on the bench.
Juventus vs. Napoli line-ups
Juventus: Di Gregorio; Savona, Kalulu, Bremer, Cambiaso; Locatelli, McKennie; Nico Gonzalez, Koopmeiners, Yildiz; Vlahovic
Napoli: Meret; Di Lorenzo, Rrahmani, Buongiorno; Politano, Anguissa, Lobotka, McTominay, Olivera; Kvaratskhelia, Lukaku
Match statistic
Ideally it would be Danilo and Douglas Luis over Savona and McKennie.