Juventus rest Danilo to make sure he can face Inter, with Dusan Vlahovic and Arkadiusz Milik upfront, but Empoli are revitalised under new coach Davide Nicola.
It kicks off at the Allianz Juventus Stadium in Turin at 17.00 GMT.
The Bianconeri are on a roll of five straight Serie A victories and another here would put them four points clear of Inter, who play tomorrow and have another game in hand.
Next week is the Scudetto showdown at San Siro, so Danilo is rested because he is one card away from suspension, replaced by Alex Sandro.
Federico Chiesa, Adrien Rabiot, Mattia De Sciglio and new signing Tiago Djaló are unavailable, so Fabio Miretti again starts, but Milik is chosen ahead of Kenan Yildiz.
Paul Pogba and Nicoló Fagioli of course remain long-term absentees due to off the field issues.
Empoli looked doomed to relegation, but the arrival of miracle specialist Nicola has already made a huge impact, as on his debut they flattened Monza 3-0.
January signing Szymon Zurkowski scored a hat-trick and starts here again, though Simone Bastoni, Viktor Kovalenko, Mattia Destro, Gabriele Guarino and Tyronne Ebuehi are injured.
Francesco Caputo is not at 100 per cent either, so Alberto Cerri and Nicoló Cambiaghi complete the attack.
Juventus: Szczesny; Gatti, Bremer, Alex Sandro; Cambiaso, McKennie, Locatelli, Miretti, Kostic; Milik, Vlahovic
Empoli: Caprile; Ismajli, Walukiewicz, Luperto; Cacace, Zurkowski, Grassi, Maleh, Gyasi; Cambiaghi, Cerri
Player statistic
| Arkadiusz Milik |  |
18' | ||
| 19' |  |
Sebastian Walukiewicz |
| Dusan Vlahovic |  |
50' | ||
| 70' | |
Tommaso Baldanzi (Assist: Sebastiano Luperto) | ||
| Timothy Weah | |
90+3' |
Match statistic
