Lazio have Luis Alberto back in the starting XI with Felipe Anderson as a False 9 as they seek revenge against giant-killers Lecce.
It kicks off at the Stadio Olimpico at 11.30 GMT.
When these sides met in August, Lecce came back from a goal down to win 2-1 and Lazio have managed just one point from their last four games against the Salentini.
However, Maurizio Sarri’s side are on a roll after three straight Serie A victories and eliminating Roma in the Coppa Italia quarter-final midweek.
It came at a cost, as Taty Castellanos picked up a muscular problem and Ciro Immobile is still not at 100 per cent either, so Felipe Anderson is the False 9, although he too had a calf issue in training yesterday.
Luis Alberto makes his big comeback and is trying to get back to full fitness for the upcoming Supercoppa Italiana Final Four in Riyadh, where Lazio face Inter on Friday.
Ivan Provedel missed the derby with Roma after suffering from flu, but he is back in goal.
Lecce miss Nicola Sansone, Kastriot Dermaku, Hamza Rafia, Lameck Banda and Ahmed Touba.
Lazio: Provedel; Marusic, Patric, Gila, Pellegrini; Guendouzi, Rovella, Luis Alberto; Isaksen, Felipe Anderson, Zaccagni
Lecce: Falcone; Gendrey, Pongracic, Baschirotto, Gallo; Kaba, Ramadani, Gonzalez; Almqvist, Krstovic, Oudin
Player statistic
| Mattia Zaccagni |  |
45' | ||
| 45' | |
Valentin Gendrey |
| Felipe Anderson (Assist: Luis Alberto) |
 |
58' | ||
| 75' | |
Lorenzo Venuti | ||
| Mattéo Guendouzi | |
77' | ||
| 81' | |
Ylber Ramadani | ||
| Matías Vecino | |
89' | ||
| Ciro Immobile | |
90+3' | ||
| 90+3' | |
Marin Pongracic |
Match statistic
