Paulo Dybala, Romelu Lukaku and new signing Dean Huijsen start for Roma in the Coppa Italia quarter-final Derby della Capitale against a Lazio side troubled by injuries.
It kicks off at the Stadio Olimpico at 17.00 GMT.
The winner must be decided tonight, after 90 minutes, extra time or even penalties, and will go on to face Juventus or Frosinone in the two-legged semi-finals.
Lazio have found their form with three consecutive Serie A victories, but the injury list remains extensive, missing Ciro Immobile.
Mattia Zaccagni, Gustav Isaksen and Luis Alberto are carrying knocks and not fully fit, while Ivan Provedel is suffering from flu symptoms, so 22-year-old Greek goalkeeper Christos Mandas gets his debut.
The big news is the return of Alessio Romagnoli after two months on the treatment table to face his former club.
Roma of course have been decimated for most of the season, especially now with Evan Ndicka and Houssem Aouar on international duty.
Diego Llorente and Lorenzo Pellegrini picked up knocks in the draw with Atalanta, while Renato Sanches, Chris Smalling, Tammy Abraham and Marash Kumbulla are on the treatment table.
Although they play Verona on Saturday in Serie A, there is no room for squad rotation.
Therefore, new signing Huijsen gets his first start, having already made his debut off the bench following his loan move from Juventus.
Roma have not beaten Lazio since a 3-0 result in March 2022, followed by two 1-0 defeats and a goalless draw in November.
Their Coppa Italia encounters tend to be dramatic, as after the historic 1-0 Lazio victory to lift the trophy in May 2013, they only crossed paths in the 2016-17 semi-final.
That saw Lazio win 2-0 at home and lose 3-2 away.
Roma: Rui Patricio; Huijsen, Mancini, Kristensen; Karsdorp, Cristante, Paredes, Bove, Zalewski; Dybala, Lukaku
Lazio: Mandas; Lazzari, Patric, Romagnoli, Marusic; Guendouzi, Cataldi, Vecino; Felipe Anderson, Castellanos, Zaccagni
Player statistic
| Mattia Zaccagni |  |
51' | ||
| 57' |  |
Bryan Cristante | ||
| Taty Castellanos | |
60' | ||
| Mattéo Guendouzi | |
65' | ||
| 65' | |
Gianluca Mancini | ||
| Luca Pellegrini | |
90+3' | ||
| Pedro | |
90+5' | ||
| Pedro |  |
90+6' | ||
| 90+10' |  |
Sardar Azmoun |
Match statistic
