Romelu Lukaku starts with Stephan El Shaarawy for Roma as he faces his former teammates and fans in a fiery atmosphere, including Lautaro Martinez and Hakan Calhanoglu.
It kicks off at San Siro at 17.00 GMT.
Inevitably, the match is overshadowed by the fact it is the first time Lukaku has returned to this stadium since his ugly separation from the Nerazzurri over the summer.
While Inter were negotiating a permanent deal with Chelsea after his loan spell, it emerged the Belgian was also talking to bitter rivals Juventus, then he refused to take calls from the club directors or his teammates.
Now on loan at Roma, Lukaku has eight goals in just 10 games between Serie A and the Europa League.
Ultras had planned to hand out 30,000 whistles to make the noise deafening whenever Lukaku touched the ball, but this was banned by authorities for disrupting the ability to hear the referee.
Despite that, the Curva Nord have still distributed the whistles with their fanzines.
Paulo Dybala, Lorenzo Pellegrini, Renato Sanches, Leonardo Spinazzola, Chris Smalling, Tammy Abraham and Marash Kumbulla did not make the trip, while Jose Mourinho is suspended.
El Shaarawy supports Lukaku, while Diego Llorente’s presence means Bryan Cristante can go back to his midfield role.
Inter rested Nicolò Barella, Marcus Thuram, Federico Dimarco and Francesco Acerbi in the Champions League win over RB Salzburg midweek, but they all return here with Capocannoniere Lautaro Martinez.
Only Juan Cuadrado and Marko Arnautovic remain unavailable.
Inter: Sommer; Pavard, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
Roma: Rui Patricio; Mancini, Llorente, Ndicka; Kristensen, Cristante, Paredes, Bove, Zalewski; Lukaku, El Shaarawy
Player statistic
14' | Gianluca Mancini | |||
Benjamin Pavard | 33' |
47' | Evan Ndicka | |||
50' | Leandro Paredes | |||
Hakan Calhanoglu | 56' | |||
Alessandro Bastoni | 64' | |||
68' | Bryan Cristante | |||
Marcus Thuram (Assist: Federico Dimarco) |
81' |