Milan launch several summer signings for their Serie A debuts in this trip to Bologna, including Christian Pulisic, Ruben Loftus-Cheek and Tijjani Reijnders.
It kicks off at the Stadio Dall’Ara at 19.45 UK time (18.45 GMT).
Stefano Pioli has almost a whole new squad to deal with, as Marco Pellegrino will be their ninth buy of the season, so he is also transforming their tactics to a 4-3-3.
Yunus Musah has to sit out a ban left over from his time at Valencia, while Ismael Bennacer is out for at least another three months with a torn anterior cruciate ligament.
Loftus-Cheek, Pulisic and Reijnders get their Serie A debuts straight from the starting XI, supporting Olivier Giroud and Rafael Leao.
Bologna sold Marko Arnautovic to Inter this week and so hand the attack to Joshua Zirkzee and Dan Ndoye.
Musa Barrow and Adama Soumaoro are out of action, the former expected to leave, while Riccardo Orsolini is not at 100 per cent.
New buy Giovanni Fabbian is already on the bench, just 24 hours after completing the transfer from Inter.
Bologna: Skorupski; Posch, Beukema, Lucumi, Lykogiannis; Aebischer, Dominguez; Ndoye, Ferguson, Moro; Zirkzee
Milan: Maignan; Calabria, Thiaw, Tomori, Theo Hernandez; Loftus-Cheek, Krunic, Reijnders; Pulisic, Giroud, Leao