Juventus start Angel Di Maria and Dusan Vlahovic in the first leg of the Europa League semi-final against Sevilla, who have Lucas Ocampos back.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 UK time (19.00 GMT).
The Bianconeri are currently second in Serie A, but facing the prospect of a new points penalty, realise winning the Europa League can get them into the Champions League next season.
Gleison Bremer joins Mattia De Sciglio and Kaio Jorge on the treatment table, but Federico Chiesa is benched for a more defensive 3-5-1-1 formation with Di Maria supporting Vlahovic.
Serial Europa League winners Sevilla have lifted the trophy six times, most recently in 2019-20, and like Juve dropped down this season from the Champions League group phase.
Former Milan winger Suso has not made the trip, out injured along with Tanguy Nianzou, Joan Jordan, Marcao and cup-tied Pape Gueye.
However, Lucas Ocampos is back to support Youssef En-Nesyri, with Bounou in goal, but Erik Lamela is only on the bench.
They eliminated Manchester United in the quarter-finals 5-2 on aggregate.
Juventus: Szczesny; Danilo, Bonucci, Alex Sandro; Cuadrado, Miretti, Locatelli, Rabiot, Kostic; Di Maria; Vlahovic
Sevilla: Bounou; Jesus Navas, Badé, Gudelj, Acuna; Rakitic, Fernando; Ocampos, Torres, Bryan Gil; En-Nesyri
Ref: Siebert (GER)
Player statistic
26' | Youssef En-Nesyri (Assist: Lucas Ocampos) | |||
Adrien Rabiot | 43' |
72' | Ivan Rakitic | |||
Manuel Locatelli | 77' | |||
78' | Bryan Gil | |||
Federico Chiesa | 79' | |||
82' | Loïc Badé | |||
Federico Gatti (Assist: Paul Pogba) |
90+7' | |||
90+3' | Erik Lamela |