Ciro Immobile returns to the starting XI for second-placed Lazio, while Juventus look to Angel Di Maria and Dusan Vlahovic, but Max Allegri is left at home.
It kicks off at the Stadio Olimpico at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens from today’s Serie A games on the LIVEBLOG.
Maurizio Sarri’s men have the opportunity to further consolidate second place, as the chasing pack continue to trip up with Inter and Milan both held to draws on Friday.
However, Juve argue that without the 15-point penalty, which will be appealed on April 19, they would be the closest to leaders Napoli.
The big news for Lazio is the return of Immobile to the starting XI, while Adam Marusic is also back after suspension.
The Biancocelesti have amassed five wins and a draw in the last six rounds, all without conceding a single goal.
Juve have a packed fixture list, fresh off the chaotic 1-1 Coppa Italia semi-final draw with Inter and preparing for the Europa League quarter-final against Sporting CP.
They’ve won seven of the last eight Serie A games and go into this clash without suspended Moise Kean, injured Mattia De Sciglio, Paul Pogba and Kaio Jorge.
Also absent is coach Allegri, who has remained in Turin after suffering from flu symptoms, so assistant manager Marco Landucci takes over on the touchline.
Di Maria and Filip Kostic support Vlahovic, though Federico Chiesa is expected to come off the bench.
Juve have not lost to Lazio since a pair of 3-1 results in December 2019, in both Serie A and the Supercoppa Italiana, followed by five wins and two draws in all competition.
Lazio: Provedel; Marusic, Casale, Romagnoli, Hysaj; Milinkovic Savic, Cataldi, Luis Alberto; Felipe Anderson, Immobile, Zaccagni
Juventus: Szczesny; Gatti, Bremer, Alex Sandro; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Di Maria; Vlahovic
Player statistic
Sergej Milinkovic-Savic (Assist: Mattia Zaccagni) |
38' | |||
42' | Adrien Rabiot | |||
45' | Alex Sandro | |||
45+3' | Manuel Locatelli |
51' | Juan Cuadrado | |||
Mattia Zaccagni (Assist: Luis Alberto) |
53' | |||
Ivan Provedel | 78' | |||
Sergej Milinkovic-Savic | 86' | |||
90+5' | Fabio Miretti |