The pressure is on Milan after Napoli and Inter victories, with Olivier Giroud and Rafael Leao leading the way against Marko Arnautovic’s Bologna.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
The Rossoneri need a win to stay three points clear at the top of the table and bring back Sandro Tonali to bolster the midfield, sending Franck Kessie to the bench.
Junior Messias, Brahim Diaz and Rafael Leao support centre-forward Giroud, with Zlatan Ibrahimovic not yet ready to start.
The only remaining absentees are Alessio Romagnoli, Simon Kjaer and Tiemoue Bakayoko.
Bologna play their first game since coach Sinisa Mihajlovic went back into hospital for leukaemia treatment, as the illness is rearing its head again after the initial July 2019 diagnosis.
Lorenzo De Silvestri and Nico Dominguez are out injured, so Aaron Hickey switches to the right wing, moving Mitchell Dijks in at left.
Arnautovic is supported by Musa Barrow and Michel Aebischer, sending Riccardo Orsolini and Roberto Soriano to the bench.
Milan: Maignan; Calabria, Kalulu, Tomori, Theo Hernandez; Tonali, Bennacer; Messias, Brahim Diaz, Leao; Giroud
Bologna: Skorupski; Soumaoro, Medel, Theate; Hickey, Schouten, Svanberg, Dijks; Aebischer, Barrow; Arnautovic