Inter rely on Lautaro Martinez and Ivan Perisic in the Europa League Round of 16, while Eintracht Frankfurt have star men Sebastien Haller and Luka Jovic, but reshuffle without Ante Rebic.
The first leg kicks off in Frankfurt at 17.55 GMT.
You can follow all the build-up and action as it happens from this game and Napoli-RB Salzburg on the LIVEBLOG.
Inter rely on Lautaro Martinez and Ivan Perisic in the Europa League Round of 16, while Eintracht Frankfurt have star men Sebastien Haller and Luka Jovic, but reshuffle without Ante Rebic.
The first leg kicks off in Frankfurt at 17.55 GMT.
The Nerazzurri are still without Mauro Icardi, officially due to a knee injury, while Radja Nainggolan and Keita Balde Diao are also on the treatment table.
Joao Miranda, Roberto Gagliardini and Dalbert are not on the UEFA list due to Financial Fair Play considerations, but Marcelo Brozovic and Milan Skriniar return from suspension.
It means Lautaro Martinez is again the only real option as centre-forward, with Perisic, Borja Valero and Matteo Politano in support.
Birthday boy Luciano Spalletti had been tempted to switch to 4-3-3 in Nainggolan’s absence, but instead uses Borja Valero in that more advanced role.
Eintracht Frankfurt beat Lazio home and away in the group stage, with a very fast-paced and aggressive style of football, so are particularly tricky customers for an Inter side low on confidence following a Serie A defeat to Cagliari.
Ante Rebic is unavailable due to a knee injury sustained at the weekend against Hoffenheim, missing out along with defender Timothy Chandler and midfielder Lucas Torro.
Jovic and Haller therefore lead the way in what appears to be a 4-4-2, despite rumours Mijat Gacinovic would adopt the trequartista role in the usual 3-4-1-2 system.
Unlike Inter, Eintracht are having a fantastic start to the new year and are still unbeaten in 2019, while they are also yet to lose in the Europa League this season and are the tournament’s top scorers with 23 goals in eight games.
Eintracht Frankfurt: Trapp; Da Costa, Hasebe, Hinteregger, N’Dicka; Gacinovic, Rode, Fernandes, Kostic; Haller, Jovic
Eintracht bench: Rønnow, Russ, Falette, Willems, De Guzman, Stendera, Paciencia
Inter: Handanovic; D'Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic; Politano, Borja Valero, Perisic; Lautaro Martinez
Inter bench: Padelli, Miranda, Ranocchia, Cedric, Schirò, Candreva, Merola
Ref: Collum (SCO)