Simone Inzaghi will look to Marcus Thuram and Lautaro Martinez in a Supercoppa semifinal against Lazio, while Ciro Immobile is favourite over Gustav Isaksen for the Biancocelesti.
It kicks off at 19:00 GMT at the Al-Awwal Park Stadium in Riyadh and the winner will face Napoli in the Final on Monday. The defending Serie A champions beat Fiorentina 3-0 on Thursday.
Inter have travelled to Saudi Arabia without the injured Juan Cuadrado, but the rest of the team is available. Therefore, Inzaghi is expected to line up Thuram and Lautaro up front and Nicolò Barella in central midfield, while Matteo Darmian is favourite over Denzel Dumfries on the right flank.
Nicolò Rovella didn’t complete a full training session with Lazio on Thursday, so he is not expected to start in midfield for the Biancocelesti. Matias Vecino is favourite over Luis Alberto, but they could both start if Danilo Cataldi goes on the bench.
Immobile is not fully fit but returned to action in a Serie A game against Lecce last week. He is expected to start in attack with Mattia Zaccagni and Felipe Anderson, but if the Italian is replaced by Isaksen, Anderson will play as a false nine.
Inter-Lazio, probable line-ups
Inter (3-5-2): Sommer; Pavard, Acerbi, Bastoni; Darmian, Barella, Calhanoglu, Mkhitaryan, Dimarco; Thuram, Lautaro.
Lazio (4-3-3): Provedel; Lazzari, Gila, Romagnoli, Marusic; Vecino, Cataldi, Guendouzi; Felipe Anderson, Immobile, Zaccagni