Ciro Immobile is flanked by Pedro, Felipe Anderson and Sergej Milinkovic-Savic, while Salernitana rely on Franck Ribery and Nwanwko Simy in a curious sort of derby.
It kicks off at the Stadio Olimpico at 17.00 GMT.
This is a curious fixture, because technically the two clubs are owned by the same man, Lazio President Claudio Lotito.
As there are rules barring dual ownership in the same division, Salernitana’s promotion to Serie A after 22 years caused problems for Lotito, who had to put the club in a blind trust awaiting sale.
Maurizio Sarri seems to have found his ideal XI and is keeping squad rotation to a minimum, with Immobile now the all-time Lazio top scorer on 160 goals.
Manuel Lazzari is the only injury absentee, while Salernitana have seen improvements since sacking Fabrizio Castori to bring in Stefano Colantuono.
Ribery is the experienced figure in the trequartista role behind Simy and Federico Bonazzoli.
Grigoris Kastanos is suspended, with Mamadou Coulibaly, Matteo Ruggeri and Leonardo Capezzi injured.
Lazio: Reina; Hysaj, Luiz Felipe, Acerbi, Marusic; Milinkovic-Savic, Cataldi, Luis Alberto; Pedro, Immobile, Felipe Anderson
Salernitana: Belec; Zortea, Strandberg, Gyomber, Ranieri; Schiavone, Di Tacchio, Obi; Ribery; Simy, Bonazzoli