Roma have Paulo Dybala back in the starting XI with Romelu Lukaku and Stephan El Shaarawy against giant-killers Lecce.
It kicks off at the Stadio Olimpico at 17.00 GMT.
Jose Mourinho has some good news from the treatment table, as after a month out Dybala is back in the line-up with Lukaku and El Shaarawy.
Renato Sanches and Leonardo Spinazzola are only fit for the bench, with Chris Smalling, Lorenzo Pellegrini, Tammy Abraham and Marash Kumbulla out of action.
Leandro Paredes is also suspended, so Edoardo Bove and Houssem Aouar start in midfield.
Lecce had such a strong start to the season, beating Lazio, Salernitana and Genoa while drawing with Fiorentina and Monza.
However, they hit the brakes lately with only two points from five rounds and were knocked out of the Coppa Italia by Parma 4-2 on Wednesday.
Kastriot Dermaku is still out of action, but Alexis Blin and Mohamed Kaba return to the squad.
Nikola Krstovic remains the danger man upfront with four goals in nine Serie A games.
Roma: Rui Patricio; Mancini, Llorente, Ndicka; Karsdorp, Bove, Cristante, Aouar, El Shaarawy; Dybala, Lukaku
Lecce: Falcone; Gendrey, Pongracic, Baschirotto, Dorgu; Kaba, Ramadani, Rafia; Almqvist, Krstovic, Banda
Player statistic
| Romelu Lukaku |  |
5' | ||
| 17' |  |
Lameck Banda | ||
| 27' | |
Patrick Dorgu |
| 71' |  |
Pontus Almqvist (Assist: Lameck Banda) | ||
| Renato Sanches | |
76' | ||
| 77' | |
Ylber Ramadani | ||
| 81' | |
Ahmed Touba | ||
| 87' | |
Gabriel Strefezza | ||
| Diego Llorente | |
89' | ||
| Sardar Azmoun (Assist: Nicola Zalewski) |
|
90+1' | ||
| Romelu Lukaku (Assist: Paulo Dybala) |
|
90+4' | ||
| Romelu Lukaku | |
90+6' |
Match statistic
