Juventus hope Federico Chiesa and Moise Kean can keep the positive streak going, but Cagliari found their form too with back-to-back wins.
It kicks off at the Allianz Juventus Stadium in Turin at 17.00 GMT.
The Bianconeri can spend the night top of the table with a victory, having won four on the bounce already and suffering only one defeat all season.
Defensive strength is the key with six consecutive clean sheets, but scoring only six in the process.
Adrien Rabiot is suspended, with Timothy Weah, Danilo, Alex Sandro and Mattia De Sciglio injured, while Paul Pogba and Nicolò Fagioli are banned due to off the field issues.
Therefore Max Allegri is forced into midfield changes, but Kean is again preferred to Dusan Vlahovic.
Claudio Ranieri’s Cagliari have really found their form after a disastrous start to the campaign, winning two on the bounce, sparked by that incredible comeback from 3-0 down at the 70th minute to beat Frosinone 4-3.
Nahitan Nandez, Alessandro Di Pardo, Elio Capradossi and Marko Rog are out of action, but Nicolas Viola and Andrea Petagna get into the starting XI with pacey Zito Luvumbo.
Gabriele Zappa also steps in at right-back after his winning goal against Genoa.
Juventus: Szczesny; Gatti, Bremer, Rugani; Cambiaso, McKennie, Locatelli, Miretti, Kostic; Chiesa, Kean
Cagliari: Scuffet; Zappa, Goldaniga, Dossena, Augello; Makoumbou, Prati, Jankto; Viola; Petagna, Luvumbo
Player statistic
| Weston McKennie |  |
57' | ||
| Bremer (Assist: Filip Kostic) |
 |
60' | ||
| Daniele Rugani | |
70' | ||
| 70' | |
Zito Luvumbo | ||
| 75' | |
Alberto Dossena (Assist: Jakub Jankto) | ||
| Filip Kostic | |
82' | ||
| Andrea Cambiaso | |
87' |
Match statistic
