Andrea Belotti is expected to start in Fiorentina‘s attack against Lazio, but Maurizio Sarri is short of options in defence.
It kicks off at 19:45 GTM at the Stadio Franchi in Florence.
The Tuscans are without the injured Dodo, Gaetano Castrovilli, Oliver Christensen and Christian Kouame. The latter was released from hospital on Sunday after undergoing treatment for malaria.
Luca Ranieri is favourite over Lucas Martinez Quarta in central defence, while Michael Kayode is expected to start as a right-back. Giacomo Bonaventura could start on the bench again, making room for Lucas Beltran.
Lazio are without the injured Patric and Nicolò Rovella, while Mario Gila is suspended.
Captain Alessio Romagnoli is fit to start, but the only other first-team centre-back available is Nicolò Casale, who has a fever and is not at his best.
Felipe Anderson, Gustav Isaksen and Ciro Immobile will start in a front three even if Mattia Zaccagni is available on the bench.
Fiorentina-Lazio, probable line-ups
Fiorentina (4-2-3-1): Terracciano; Kayode, Milenkovic, Ranieri, Biraghi; Arthur, Duncan; Ikone, Beltran, Gonzalez; Belotti.
Lazio (4-3-3): Provedel; Lazzari, Casale, Romagnoli, Marusic; Guendouzi, Cataldi, Luis Alberto; Isaksen, Immobile, F. Anderson.