Lazio have three big decisions to make in their head-to-head with Atalanta, while Josip Ilicic is the main concern for Gian Piero Gasperini.
It kicks off at 14.00 UK time (13.00 GMT).
The Bergamo Boys currently sit in fourth place on 59 points, but Lazio are on 55 in eighth, so the fight for Europe will go down to the wire.
On top of that, these two teams will also face off in the Coppa Italia Final at the Stadio Olimpico on May 15.
Lazio have three big decisions to make in their head-to-head with Atalanta, while Josip Ilicic is the main concern for Gian Piero Gasperini.
It kicks off at 14.00 UK time (13.00 GMT).
The Bergamo Boys currently sit in fourth place on 59 points, but Lazio are on 55 in eighth, so the fight for Europe will go down to the wire.
On top of that, these two teams will also face off in the Coppa Italia Final at the Stadio Olimpico on May 15.
Lazio go in with a few selection headaches for Coach Simone Inzaghi, as Senad Lulic is suspended with Sergej Milinkovic-Savic, Stefan Radu, Valon Berisha, Patric and Jordan Lukaku injured.
Goalkeeper Thomas Strakosha picked up a back problem in training, but should be fit to start, while Wallace is the favourite to play in defence rather than Luiz Felipe.
The latest rumours suggest Romulo will retain his place on the right wing, moving Adam Marusic over to the left.
Despite scoring a brace to beat Sampdoria 2-1 last week, Felipe Caicedo could be benched in favour of the Joaquin Correa-Ciro Immobile partnership.
Atalanta have relatively few question marks over their line-up, as Rafael Toloi and Musa Barrow are out of action, with Robin Gosens not 100 per cent fit, so Timothy Castagne is expected to take the left flank.
Papu Gomez and Duvan Zapata are natural first choices in attack, but Ilicic remains in doubt after his recurring knee issue forced him to miss the 2-0 win over Udinese.
If the Slovenian is not risked from the start, then Mario Pasalic should take the trequartista role, pushing Gomez into the more advanced position.
Expect Ilicic to come on as a substitute even if he isn’t in the initial XI.
Atalanta need to be careful, as they have several players who are one yellow card away from a Serie A ban: Andrea Masiello, Remo Freuler, Jose Luis Palomino, Hans Hateboer, Gianluca Mancini, Ilicic and Gomez.
Probable line-ups
Lazio (3-5-2): Strakosha; Wallace, Acerbi, Bastos; Romulo, Parolo, Leiva, Luis Alberto, Marusic; Correa, Immobile
Atalanta (3-4-1-2): Gollini; Mancini, Palomino, Masiello; Hateboer, Freuler, De Roon, Castagne; Pasalic/Ilicic, Gomez; Zapata