Cagliari hope Radja Nainggolan, Joao Pedro and Giovanni Simeone can get them back on track against struggling Udinese.
It kicks off at the Dacia Arena at 14.00 GMT.
You can follow all the action as it happens from this game, Inter–Genoa and Torino-SPAL on the LIVEBLOG.
The Sardinians had been unbeaten in 13 matches when that run came to a dramatic end against Lazio on Monday evening.
Cagliari hope Radja Nainggolan, Joao Pedro and Giovanni Simeone can get them back on track against struggling Udinese.
It kicks off at the Dacia Arena at 14.00 GMT.
You can follow all the action as it happens from this game, Inter-Genoa and Torino-SPAL on the LIVEBLOG.
The Sardinians had been unbeaten in 13 matches when that run came to a dramatic end against Lazio on Monday evening.
They were leading 1-0 until conceding two goals in stoppages for a 2-1 defeat.
Nahitan Nandez joins goalkeeper Robin Olsen on the list of suspended players, but Marko Rog returns from his ban to fill in the midfield gaps.
Luca Ceppitelli, Valter Birsa, Lucas Castro, Alessio Cragno and Leonardo Pavoletti are still out injured.
Nainggolan again takes the reins behind strikers Joao Pedro and Cholito Simeone.
As for Udinese, they are still under caretaker manager Luca Gotti, having sacked Igor Tudor on November 1, but been in no rush to find a permanent replacement.
They sit only two points clear of the relegation zone, managing two draws in the last five Serie A games.
Defender Samir is out for a couple of months following knee surgery, but Ken Sema and Mato Jajalo return from injury.
Rodrigo De Paul and Rolando Mandragora try to provide some creativity behind Stefano Okaka and Kevin Lasagna.
These teams have not shared the spoils since a 2-2 draw in Udine in January 2015, followed by four Cagliari victories and three Udinese successes.
Udinese: Musso; De Maio, Troost-Ekong, Nuytinck; Stryger-Larsen, Fofana, Mandragora, De Paul, Sema; Okaka, Lasagna
Cagliari: Rafael; Faragò, Pisacane, Klavan, Lykogiannis; Ionita, Cigarini, Rog; Nainggolan; Joao Pedro, Simeone
Ref: Piccinini