Napoli revamp yet again for their trip to Udinese, as Dries Mertens and Arkadiusz Milik start with Simone Verdi.
It kicks off at the Dacia Arena at 19.30 UK time (18.30 GMT).
Follow the build-up and action as it happens from all three Serie A games on the LIVEBLOG.
Carlo Ancelotti has changed his line-up every time this season and the biggest shift here sees Lorenzo Insigne left behind with a muscular problem.
Napoli revamp yet again for their trip to Udinese, as Dries Mertens and Arkadiusz Milik start with Simone Verdi.
It kicks off at the Dacia Arena at 19.30 UK time (18.30 GMT).
Follow the build-up and action as it happens from all three Serie A games on the LIVEBLOG.
Carlo Ancelotti has changed his line-up every time this season and the biggest shift here sees Lorenzo Insigne left behind with a muscular problem.
Adam Ounas, Sebastiano Luperto, Faouzi Ghoulam, Vlad Chiriches and Amin Younes are also out of action.
Verdi and Jose Callejon therefore take the wings, with a new front two of Mertens and Milik.
The last Serie A game that Napoli played without Insigne was in December 2017, so this ends a run of 36 consecutive matches.
Orestis Karnezis, Allan and Piotr Zielinski all face their former club.
Udinese have lost three on the bounce with their new Coach Julio Velazquez and have a poor record against Napoli, losing the last four meetings.
Emmanuel Badu, Svante Ingelsson, Giuseppe Pezzella and Darwin Machis are unavailable, but Kevin Lasagna hopes to build on his recent Italy debut with support from Rodrigo De Paul.
Udinese: Scuffet; Stryger-Larsen, Troost-Ekong, Nuytinck, Samir; Behrami; Pussetto, Fofana, Mandragora; De Paul; Lasagna
Napoli: Karnezis; Malcuit, Albiol, Koulibaly, Hysaj; Callejon, Allan, Zielinski, Verdi; Mertens, Milik
Napoli bench: Ospina, D’Andrea, Maksimovic, Mario Rui, Fabian, Rog, Diawara, Hamsik