Sassuolo have their trio of star strikers back, but host Fiorentina with Alessandro Diamanti and Mohamed Salah.
It kicks off at the Mapei Stadium in Reggio Emilia at 17.00 GMT, click here for a match preview.
These two teams play some of the most attacking and attractive football in Serie A, so it could well be an entertaining encounter.
Sassuolo have their trio of star strikers back, but host Fiorentina with Alessandro Diamanti and Mohamed Salah.
It kicks off at the Mapei Stadium in Reggio Emilia at 17.00 GMT, click here for a match preview.
These two teams play some of the most attacking and attractive football in Serie A, so it could well be an entertaining encounter.
Sassuolo earned a 1-1 draw at Sampdoria last week despite having the entire trident attack suspended, but Simone Zaza, Domenico Berardi and Nicola Sansone return today.
Saphir Taider is banned with Sime Vrsaljko, Federico Peluso, Gianluca Pegolo and Emanuele Terranova injured.
Eusebio Di Francesco has been tipped for a future on the Viola bench if Vincenzo Montella moves on.
Fiorentina are on sparkling form with one defeat in 11 games taking them up to joint fourth place, despite selling Juan Cuadrado to Chelsea.
They received Mohamed Salah in exchange and he gets his first Serie A start this evening alongside inspired Diamanti and pacey young striker Khouma Babacar.
Mario Gomez receives a well-deserved rest, while the absentee list includes Juan Manuel Vargas, Giuseppe Rossi and Federico Bernardeschi.
A move to the 4-3-3 system gives Micah Richards a rare start.
Sassuolo: Consigli; Gazzola, Cannavaro, Acerbi, Longhi; Brighi, Magnanelli, Biondini; Berardi, Zaza, Sansone
Sassuolo bench: Pomini, Polito; Bianco, Antei, Caselli, Chibsah, Missiroli, Donis, Floro Flores, Floccari, Lazarevic
Fiorentina: Tatarusanu; Richards, Savic, G Rodriguez, Alonso; Kurtic, Pizarro, Mati Fernandez; Diamanti, Babacar, Salah
Fiorentina bench: Rosati; Tomovic, Pasqual, Rosi, Vargas, Badelj, Joaquin, Aquilani, Borja Valero, Ilicic, Gomez, Gilardino