Roma face a very tricky visit to Sampdoria and are forced to reshuffle again with Edin Dzeko and Mohamed Salah facing Eder and Luis Muriel.
It kicks off at 19.45 UK time (18.45 GMT), follow all the action from this and the other seven Serie A games on our LIVEBLOG.
The Giallorossi slipped down the standings with their 2-2 draw against Sassuolo at the weekend, having to twice fight back from a goal down on home turf.
Roma face a very tricky visit to Sampdoria and are forced to reshuffle again with Edin Dzeko and Mohamed Salah facing Eder and Luis Muriel.
It kicks off at 19.45 UK time (18.45 GMT), follow all the action from this and the other seven Serie A games on our LIVEBLOG.
The Giallorossi slipped down the standings with their 2-2 draw against Sassuolo at the weekend, having to twice fight back from a goal down on home turf.
The pressure is therefore on as they enter Marassi, where Walter Zenga recovered from Europa League preliminary round disaster to win over the fans.
Eder, Muriel and Roberto Soriano are on sparkling form, though Angelo Palombo, Lorenzo De Silvestri and Mattia Cassani miss out.
Ex-Roma star Antonio Cassano is on the bench and ready to come on in the second half.
Joaquin Correa is given his first start after some impressive substitute appearances.
Roma are without Francesco Totti, Antonio Rudiger and Wojciech Szczesny, so Rudi Garcia must reshuffle his pack.
Dzeko steps back in to the trident with Iago Falque and Salah, while Daniele De Rossi drops back into central defence.
Roma have a surprisingly poor record in this fixture, winning only nine times with 21 draws and 27 defeats. Last season the Blucerchiati famously conquered the Olimpico 2-0, but Samp haven’t beaten the Giallorossi at Marassi since February 2013.
Sampdoria: Viviano; Mesbah, Pereira, Silvestre, Zukanovic; Barreto, Fernando, Soriano, Correa; Eder, Muriel
Roma: De Sanctis; Florenzi, Manolas, De Rossi, Digne; Pjanic, Keita, Nainggolan; Salah, Dzeko, Falque