Napoli try to maintain their perfect start, but surprisingly rest Marek Hamsik and Jose Callejon for Amadou Diawara and Simone Verdi against Sampdoria.
It kicks off at 19.30 UK time (18.30 GMT), follow the build-up and action from all tonight’s Serie A games on the LIVEBLOG.
Napoli try to maintain their perfect start, but surprisingly rest Marek Hamsik and Jose Callejon for Amadou Diawara and Simone Verdi against Sampdoria.
It kicks off at 19.30 UK time (18.30 GMT), follow the build-up and action from all tonight’s Serie A games on the LIVEBLOG.
Carlo Ancelotti’s Napoli fought back to beat both Lazio and Milan, but he is already proving himself very different to predecessor Maurizio Sarri by rotating the squad.
Incredibly, Callejon has started every Serie A match since a 2-0 win over Genoa in February 2017 – and that’s because he was suspended – making 54 starts in a row.
The last time he sat on the bench was a 0-0 at Carpi on September 23, 2015.
Captain Hamsik has featured either in the starting XI or as a substitute in each of the last 125 Serie A games, since a 1-0 defeat to Roma on April 4, 2015.
Yet both are dropped today in favour of Diawara in the midfield playmaker role and ex-Bologna winger Verdi getting his Napoli debut in the trident attack with Arkadiusz Milik and Lorenzo Insigne.
Once again, Dries Mertens is left on the sidelines for the time being.
Sampdoria play their first home match since the collapse of the iconic Morandi bridge, which killed 43 people and left many more homeless.
There will be a minute’s silence before kick-off and the ultras have designed their own T-Shirts marking the occasion, with funds going to help the victims.
As for the team, Dennis Praet and Vasco Regini are injured, so ex-Napoli defender Lorenzo Tonelli gets his debut.
Riccardo Saponara also starts following his deadline day move from Fiorentina, while Gianluca Caprari returns from suspension, but is still on the bench.
Sampdoria have not beaten Napoli since a 1-0 result here in May 2010, followed by three draws and 11 losses, home and away.
That includes five consecutive victories for the Partenopei, but with only one clean sheet.
Sampdoria: Audero; Bereszynski, Andersen, Tonelli, Murru; Linetty, Barreto, Ekdal; Saponara; Quagliarella, Defrel
Napoli: Ospina; Hysaj, Albiol, Koulibaly, Mario Rui; Allan, Diawara, Zielinski; Verdi, Milik, Insigne
Ref: Massa