Roma field Alessandro Florenzi in yet another new role and returning Leandro Castan against Empoli.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
Follow all the build-up and action as it happens on our LIVEBLOG.
The Giallorossi need a victory to climb back up the table after criticism again rained down on Coach Rudi Garcia.
Roma field Alessandro Florenzi in yet another new role and returning Leandro Castan against Empoli.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
Follow all the build-up and action as it happens on our LIVEBLOG.
The Giallorossi need a victory to climb back up the table after criticism again rained down on Coach Rudi Garcia.
Francesco Totti and Seydou Keita are out injured, while Edin Dzeko is rested ahead of Tuesday’s Champions League clash with Bayer Leverkusen.
Leandro Castan is given a rare start and it was rumoured until very close to kick-off that Garcia would use a new 4-2-3-1 system.
Instead, it appears to be a 4-3-3 with Florenzi moved into midfield, with Iago Falque, Mohamed Salah and Gervinho in attack.
This is Daniele De Rossi’s 500th appearance in a Roma jersey.
Empoli have both Riccardo Saponara and Piotr Zielinski suspended, while Levan Mchedlidze, Uros Cosic and Daniele Croce are unavailable.
That means Bosnia international Rade Krunic is given his second consecutive Serie A start.
It’s important to watch Leandro Paredes and goalkeeper Lukasz Skorupski, who play for Empoli on loan from Roma.
Roma: Szczesny; Torosidis, Manolas, Castan, Digne; Florenzi, Pjanic, De Rossi; Iago Falque, Gervinho, Salah
Empoli: Skorupski; Zambelli, Tonelli, Barba, Mario Rui; Paredes, Diousse, Buchel; Krunic; Maccarone, Pucciarelli