Inter pull out all the stops against Pescara, fielding Joao Mario, Antonio Candreva, Ever Banega, Ivan Perisic and Mauro Icardi.
It kicks off at the Stadio Adriatico at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
Frank de Boer has managed only one point from two games in charge against Chievo and Palermo, so the pressure is already piling on the new Coach.
Inter pull out all the stops against Pescara, fielding Joao Mario, Antonio Candreva, Ever Banega, Ivan Perisic and Mauro Icardi.
It kicks off at the Stadio Adriatico at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
Frank de Boer has managed only one point from two games in charge against Chievo and Palermo, so the pressure is already piling on the new Coach.
The club spent heavily over the summer and a lot of that money will be on the pitch tonight, above all the debut of Euro 2016 winner Joao Mario after his €40m move from Sporting CP.
He goes into a new 4-2-3-1 system with Gary Medel, while Candreva, Banega and Perisic fan out behind hitman Icardi.
Yuto Nagatomo is not 100 per cent fit, so Davide Santon starts at left-back.
It’s a very special match for Gianluca Caprari, who signed for Inter this summer and remains on loan with the Delfini for one more season.
He leads the way with support from Valerio Verre and Ahmad Benali.
Other ex-Inter men in the squad include Hugo Campagnaro and Cristiano Biraghi.
New Pescara signing Alberto Aquilani is on the bench, so Gaston Brugman gets the nod with Ledian Memushaj.
Coach Massimo Oddo focuses on all-attack football and already caused an upset this season, leading Napoli 2-0 before a late comeback for 2-2.
Although Pescara lost 2-1 to Sassuolo, the result was overturned by the Disciplinary Commission due to an irregularly registered player, so technically they have four points in the table to Inter’s one.
Pescara have lost their last six meetings with Inter, home and away, but the most recent encounter was in January 2013. The Nerazzurri lost only once at the Adriatico, 2-1 in April 1978, along with four wins and a draw.
Pescara: Bizzarri; Zampano, Campagnaro, Gyomber, Biraghi; Memushaj, Brugman, Cristante; Verre, Benali; Caprari
Pescara bench: Fiorillo, Crescenzi, Bruno, Manaj, Zuparic, Bahebeck, Aquilani, Pepe, Vitturini, Mitrita, Coda, Fornasier
Inter: Handanovic; D'Ambrosio, Miranda, Murillo, Santon; Joao Mario, Medel; Candreva, Banega, Perisic; Icardi
Inter bench: Carrizo, Melo, Kondogbia, Palacio, Jovetic, Biabiany, Ranocchia, Eder, Gnoukouri, Nagatomo, Brozovic, Miangue
Ref: Damato