Roma visit their former star Antonio Cassano, but both they and Parma have an injury crisis to contend with.
It kicks off at the Stadio Tardini at 19.45 UK time (18.45 GMT), click here for a match preview.
The Giallorossi are joint top of the table with a 100 per cent record and haven’t conceded a goal yet in this Serie A season.
Roma visit their former star Antonio Cassano, but both they and Parma have an injury crisis to contend with.
It kicks off at the Stadio Tardini at 19.45 UK time (18.45 GMT), click here for a match preview.
The Giallorossi are joint top of the table with a 100 per cent record and haven’t conceded a goal yet in this Serie A season.
However, Rudi Garcia finds himself without Juan Manuel Iturbe, Daniele De Rossi, Leandro Castan, Davide Astori, Salih Ucan, Kevin Strootman, Marco Borriello and Federico Balzaretti.
That means Mapou Yanga-Mbiwa starts for the second game running, while Seydou Keita fills the midfield gaps.
Francesco Totti leads the way against his old friend Cassano, who has found some degree of maturity at Parma.
FantAntonio is fresh from a brace to beat Chievo 3-2 and would love to put more goals past his former club.
Parma also have an injury crisis, as Jonathan Biabiany, Gabriel Paletta, Mattia Cassani and Bidaoui are sidelined.
Massimo Coda came off the bench to change the game against Chievo, but is not given a chance in the starting XI.
Roma conquered the Tardini 3-1 last season.
Parma: Mirante; Mendes, Lucarelli, Felipe, De Ceglie; Acquah, Lodi, Mauri; Palladino, Cassano, Belfodil
Roma: De Sanctis; Torosidis, Manolas, Yanga-Mbiwa, Holebas; Pjanic, Keita, Nainggolan; Ljajic, Totti, Gervinho