Inter start Ivan Perisic, Mauro Icardi and Stevan Jovetic as they seek their first victory in Palermo for five years.
It kicks off at 19.45 UK time (18.45 GMT). Follow all the build-up and action on our LIVEBLOG.
The Nerazzurri haven’t conquered the Stadio Barbera since 2010 and scraped only two points from the last three Serie A rounds.
Inter start Ivan Perisic, Mauro Icardi and Stevan Jovetic as they seek their first victory in Palermo for five years.
It kicks off at 19.45 UK time (18.45 GMT). Follow all the build-up and action on our LIVEBLOG.
The Nerazzurri haven’t conquered the Stadio Barbera since 2010 and scraped only two points from the last three Serie A rounds.
Fredy Guarin and Gary Medel form a new midfield with Geoffrey Kondogbia, who scored against Milan in Wednesday’s Trofeo Berlusconi friendly, as Felipe Melo is rested.
Jovetic, Icardi and Perisic complete the attack, though the Croatian could be in a deeper role between the lines.
The big surprises are in the full-back positions, where Yuto Nagatomo and Alex Telles get rare starts.
The Japan international managed only 10 minutes against Carpi this season.
Palermo ended their run of four consecutive defeats by beating Bologna last week and are eager to build momentum.
Franco Vazquez supports Alberto Gilardino, who has already put seven Serie A goals past Inter in his career.
Oscar Hiljemark gets the nod ahead of Mato Jajalo in midfield with veteran Enzo Maresca.
Michel Morganella, Uros Djurdjevic and Francesco Bolzoni are injured.
Palermo: Sorrentino; Struna, Gonzalez, Andelkovic; Rispoli, Rigoni, Maresca, Hiljemark, Lazaar; Vazquez, Gilardino
Palermo bench: Colombi, Vitiello, Goldaniga, Trajkovski, Brugman, Chochev, Quaison, Jajalo, Daprela’, El Kaoutari, La Gumina, Pezzella
Inter: Handanovic; Nagatomo, Miranda, Murillo, Telles; Guarin, Medel, Kondogbia; Jovetic, Perisic; Icardi
Inter bench: Carrizo, Juan Jesus, Palacio, Biabiany, Montoya, Santon, Ljajic, Ranocchia, D’Ambrosio, Brozovic, Melo, Manaj