Manolo Gabbiadini is benched and Ciro Immobile starts against his hometown club as Napoli and Lazio go head-to-head for third place.
It kicks off at 19.45 GMT, follow all the action as it happens from Torino-Cagliari and Napoli-Lazio on the LIVEBLOG.
The Partenopei just haven’t found their feet since Arkadiusz Milik and Raul Albiol injuries, stuttering both in Serie A and the Champions League with only two wins from their last seven.
Manolo Gabbiadini is benched and Ciro Immobile starts against his hometown club as Napoli and Lazio go head-to-head for third place.
It kicks off at 19.45 GMT, follow all the action as it happens from Torino-Cagliari and Napoli-Lazio on the LIVEBLOG.
The Partenopei just haven’t found their feet since Arkadiusz Milik and Raul Albiol injuries, stuttering both in Serie A and the Champions League with only two wins from their last seven.
Gabbiadini has struggled to make an impact as a centre-forward, a role he seems ill-suited to, and is therefore benched in favour of Dries Mertens as a False Nine.
Lorenzo Insigne will be eager to impress after earning his return to the Italy squad for upcoming games against Liechtenstein and Germany.
Marek Hamsik rescued Napoli with a cracking strike in the 1-1 Champions League draw with Besiktas midweek.
Lazio are on impressive form and especially their hitman Immobile, who has been linked with Napoli many times, being a native of this city.
He is also a very old friend of Insigne, as they were teammates in Serie B with Pescara – a side that included Marco Verratti.
The Aquile are without Stefan de Vrij, Jordan Lukaku, Luis Alberto and Bastos, but have a remarkable trio of Immobile, Keita Balde Diao and Felipe Anderson.
Lucas Biglia is fit enough to start at long last, while Sergej Milinkovic-Savic and Stefan Radu are also back.
Both sides have failed to find the net only twice this season.
The last six Serie A meetings between them have provided a total of 26 goals, home and away.
Last term Lazio were flattened here 5-0, but in recent years this fixture also ended 4-2 for the visitors, 4-2 for the hosts and an epic comeback for Napoli to triumph 4-3 in April 2011.
Napoli: Reina; Hysaj, Chiriches, Koulibaly, Ghoulam; Zielinski, Diawara, Hamsik; Callejon, Mertens, Insigne
Napoli bench: Sepe, Rafael, Maksimovic, Strinic, Tonelli, Maggio, Rog, Jorginho, Allan, El Kaddouri, Giaccherini, Gabbiadini
Lazio: Marchetti; Basta, Wallace, Radu; Felipe Anderson, Parolo, Biglia, Milinkovic-Savic, Lulic; Keita, Immobile
Lazio bench: Strakosha, Vargic, Patric, Bastos, Kishna, Hoedt, Vinicius, Cataldi, Murgia, Leitner, Lombardi, Djordjevic