Lazio rely on Miroslav Klose and Federico Marchetti during an injury crisis, while Udinese look to Luis Muriel.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
Lazio rely on Miroslav Klose and Federico Marchetti during an injury crisis, while Udinese look to Luis Muriel.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
This fixture concludes Serie A Week 4.
The Biancocelesti wasted numerous scoring opportunities in their 1-0 defeat to Genoa, which also saw Stefan de Vrij sent off.
That means the Dutch international defender is suspended with Lucas Biglia, Stefan Radu, Ederson and Alvaro Gonzalez.
The season is almost over for Santiago Gentiletti, who snapped his anterior cruciate ligament and will be out for at least six months.
Dusan Basta is also ruled out against his former club after fracturing a bone in his hand, but Federico Marchetti gets his season debut after an injury lay-off.
Veteran Klose leads the attack with Felipe Anderson and Antonio Candreva, who is fresh from signing a contract extension.
Udinese are fresh from a surprise 1-0 win over Napoli, but rest Antonio Di Natale for this midweek round.
Instead, Colombia international Muriel partners ex-Chievo striker Cyril Thereau.
The injury list includes Gabriel Silva, Simone Scuffet and Maurizio Domizzi.
Lazio: Marchetti; Konko, Cana, Novaretti, Braahfeid; Parolo, Ledesma, Onazi; Felipe Anderson, Klose, Candreva
Lazio bench: Berisha, Strakosha, Ciani, Mauri, Djordjevic, Keita, Pereirinha, Lulic, Cavanda, Tounkara, Murgia
Udinese: Karnezis; Widmer, Heurtaux, Danilo, Piris; Allan, Guilherme, Badu; Kone, Thereau; Muriel
Udinese bench: Brkic, Meret, Belmonte, Bubnjic, Coda, Pasquale, Jadson, Hallberg, Lucas Evangelista, Bruno Fernandes, Di Natale, Zapata