Lazio use Felipe Anderson and Antonio Candreva together in their head-to-head with Domenico Berardi’s Sassuolo.
It kicks off at 18.00 GMT, follow the build-up and action for this and Fiorentina-Napoli on our LIVEBLOG.
The Biancocelesti are the only remaining Italian contenders for the Europa League after eliminating Galatasaray 4-2 on aggregate.
Lazio use Felipe Anderson and Antonio Candreva together in their head-to-head with Domenico Berardi’s Sassuolo.
It kicks off at 18.00 GMT, follow the build-up and action for this and Fiorentina-Napoli on our LIVEBLOG.
The Biancocelesti are the only remaining Italian contenders for the Europa League after eliminating Galatasaray 4-2 on aggregate.
Their continental form has curiously been better than in Serie A, where they’ve struggled and sit behind seventh-placed Sassuolo.
The injury crisis drags on with Stefan Radu, Dusan Basta, Santiago Gentiletti, Eddy Onazi and Stefan de Vrij on the treatment table.
It managed to get even worse over the last few hours, as Alessandro Matri and goalkeeper Federico Marchetti have been hit with the flu epidemic currently sweeping the city.
Ricardo Kishna and Ravel Morrison are at least back on the bench, while Miroslav Klose leads the attack with Felipe Anderson and Candreva.
In recent weeks Coach Stefano Pioli has tended to use one or the other, but goes for both together this time out.
Sassuolo have stated they’ll “raise the bar” and go for Europe this season, making this a decisive clash.
Karim Laribi is injured and key midfielder Simone Missiroli suspended.
Berardi is the one to watch, flanked by Gregoire Defrel and Nicola Sansone.
Lazio: Berisha; Konko, Bisevac, Mauricio, Lulic; Milinkovic-Savic, Biglia, Parolo; Felipe Anderson, Klose, Candreva
Lazio bench: Guerrieri, Braafheid, Hoedt, Patric, Cataldi, Morrison, Mauri, Kishna, Keita, Djordjevic
Sassuolo: Consigli; Vrsaljko, Cannavaro, Acerbi, Peluso; Biondini, Magnanelli, Duncan; Berardi, Defrel, Sansone
Sassuolo bench: Pomini, Pegolo, Longhi, Antei, Gazzola, Terranova, Pellegrini, Broh, Falcinelli, Politano, Trotta