Inter form a new partnership of Romelu Lukaku and Alexis Sanchez against Roma’s Edin Dzeko and Henrikh Mkhitaryan.
It kicks off at 19.45 UK time (18.45 GMT).
The Nerazzurri are still celebrating their Scudetto and Antonio Conte is rotating his squad to give everyone a moment in the spotlight.
Inter form a new partnership of Romelu Lukaku and Alexis Sanchez against Roma’s Edin Dzeko and Henrikh Mkhitaryan.
It kicks off at 19.45 UK time (18.45 GMT).
The Nerazzurri are still celebrating their Scudetto and Antonio Conte is rotating his squad to give everyone a moment in the spotlight.
That includes goalkeeper Ionut Radu, who only made his first appearance of the season in all competition as a substitute for Samir Handanovic at the weekend in their 5-1 win over Sampdoria.
Lukaku was rested that day and returns now to partner Alexis Sanchez, giving Lautaro Martinez the night off.
Roma have no such luxury, as the injury crisis remains extensive, with Chris Smalling, Pau Lopez, Leonardo Spinazzola, Amadou Diawara, Jordan Veretout and Nicolò Zaniolo out of action.
Gonzalo Villar, Carles Perez and Stephan El Shaarawy return, as does Gianluca Mancini, who was suspended for the 5-0 win over Crotone on Sunday.
Dzeko leads the attack with Lorenzo Pellegrini, Pedro and Henrikh Mkhitaryan, while teenager Ebrima Darboe gets his second start in midfield, the three-man defence tactic now definitively shelved.
Jose Mourinho will be watching, as his former and future clubs face off at San Siro.
Curiously, each of the last six Serie A meetings between these teams have been draws.
Inter:Radu; Skriniar, Ranocchia, D'Ambrosio; Darmian, Barella, Brozovic, Vecino, Perisic; Sanchez, Lukaku
Roma: Fuzato; Karsdorp, Mancini, Kumbulla, Santon; Darboe, Cristante; Pedro, Pellegrini, Mkhitaryan; Dzeko
Ref: Chiffi