Inter aim to keep their 100 per cent record going in Serie A with Matteo Politano coming in to support Romelu Lukaku, while Lazio drop Ciro Immobile as punishment.
It kicks off at 20.00 UK time (19.00 GMT).
Inter aim to keep their 100 per cent record going in Serie A with Matteo Politano coming in to support Romelu Lukaku, while Lazio drop Ciro Immobile as punishment.
It kicks off at 20.00 UK time (19.00 GMT).
Antonio Conte has transformed the Nerazzurri in a few short weeks and they are top of the Serie A table with four wins from four.
He has a full squad to choose from, but Lautaro Martinez is rested in favour of Politano, while Stefano Sensi also goes to the bench with Alexis Sanchez.
Cristiano Biraghi makes his first start for the Nerazzurri and Samir Handanovic celebrates his 300th competitive appearance in the Inter jersey.
Lazio defender Stefan Radu didn’t make the trip to San Siro, as he is suffering from a fever, so Bastos steps into the back three.
Jordan Lukaku, Romelu’s little brother, is still out of action following surgery.
Manuel Lazzari, Luis Alberto and Sergej Milinkovic-Savic run the midfield, but the big shock is that Immobile is dropped following a touchline row with Coach Simone Inzaghi, as the striker did not take his substitution against Parma well.
He is punished with a spot on the bench, as Felipe Caicedo and Tucu Correa start upfront instead.
Jony Rodriguez and Marco Parolo are also surprise starters in place of Senad Lulic and Lucas Leiva.
The Biancocelesti got back on their feet with a 2-0 victory over Parma on Sunday, having lost their way in recent weeks with a Rome Derby draw and back-to-back losses to SPAL and Cluj.
Lazio represent something of a taboo for Inter, as they are unbeaten at San Siro since a 3-0 result in December 2016, emerging with two Serie A wins and a draw, conceding only one goal.
They also won here in the Coppa Italia last season on penalties following a dramatic 1-1 extra time draw.
In their last 22 Serie A meetings, home and away, only twice did these teams share the spoils, with Inter winning 12 and losing eight.
Inter: Handanovic; Godin, De Vrij, Skriniar; D’Ambrosio, Barella, Brozovic, Vecino, Biraghi; Politano, R Lukaku
Lazio: Strakosha; Luiz Felipe, Acerbi, Bastos; Lazzari, Milinkovic-Savic, Parolo, Luis Alberto, Jony; Correa, Caicedo
Ref: Maresca