Inter are in desperate need of a victory against struggling Sampdoria with many familiar faces on show.
It kicks off at 19.45 GMT, follow all the build-up and action from this and the Verona Derby on our LIVEBLOG.
Jose Mourinho and Ronaldo are in the stands this evening, invited by former President Massimo Moratti.
The Nerazzurri were top of the table over Christmas, but dropped to fourth place with last week’s defeat to Fiorentina.
Inter are in desperate need of a victory against struggling Sampdoria with many familiar faces on show.
It kicks off at 19.45 GMT, follow all the build-up and action from this and the Verona Derby on our LIVEBLOG.
Jose Mourinho and Ronaldo are in the stands this evening, invited by former President Massimo Moratti.
The Nerazzurri were top of the table over Christmas, but dropped to fourth place with last week’s defeat to Fiorentina.
Roberto Mancini has to do without suspended Geoffrey Kondogbia, Gary Medel and Alex Telles this evening.
Felipe Melo therefore returns in midfield with Marcelo Brozovic, while Ivan Perisic and Jonathan Biabiany provide pace down the wings.
Mauro Icardi and Eder both played for Sampdoria before coming to Inter, the latter only making the switch last month.
The same goes for Andrea Ranocchia and Dodo, who are on loan from Inter at Samp and return to San Siro as opponents.
Ricky Alvarez is a surprise starter for Samp, having joined them as a free agent following a legal battle between Inter and Sunderland.
Sampdoria are hovering just above the relegation zone and have had a dismal run under Coach Vincenzo Montella – a former teammate of Mancini at Samp.
Fabio Quagliarella has support from Inter transfer target Roberto Soriano, while Antonio Cassano – another ex-Nerazzurri man – is on the bench.
Carlos Carbonero, Modibo Diakite, Pedro Pereira and Jacopo Sala are out injured.
Sampdoria haven’t won this fixture at San Siro since December 1996 – when Mancini and Montella were on target in a crazy 4-3 result.
Inter: Handanovic; D'Ambrosio, Miranda, Murillo, Nagatomo; Biabiany, Brozovic, Felipe Melo, Perisic; Eder, Icardi
Inter bench: Carrizo, Berni, Juan Jesus, Palacio, Jovetic, Santon, Ljajic, Gnoukouri, Zonta, Popa, Manaj
Sampdoria: Viviano; Cassani, Ranocchia, Silvestre; Ivan, Soriano, Fernando, Dodò; Alvarez, Quagliarella, Correa
Sampdoria bench: Puggioni, Brignoli, Moisander, Barreto, Rodriguez, Palombo, Christodoulopoulos, Krsticic, Muriel, De Silvestri, Skriniar, Cassano