Roma use Alessandro Florenzi in a new role and Inter rely on Mauro Icardi, Joao Mario and Ivan Perisic in tonight’s showdown.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
These are two of the most unpredictable sides in Serie A and often promise plenty of goals in their matches.
Roma use Alessandro Florenzi in a new role and Inter rely on Mauro Icardi, Joao Mario and Ivan Perisic in tonight’s showdown.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
These are two of the most unpredictable sides in Serie A and often promise plenty of goals in their matches.
The Giallorossi lost at Torino last week and crushed Astra Giurgiu 4-0 on Thursday evening, so hope that home form can get them through.
Frank de Boer’s men had won three in a row in Serie A, including a 2-1 victory over Juventus, then stalled 1-1 with Bologna and were humiliated 3-1 by Sparta Prague in the Europa League.
Luciano Spalletti makes many changes, dropping Radja Nainggolan and Francesco Totti, but moving Florenzi into a new role in the trio supporting Edin Dzeko.
He’s flanked by Mohamed Salah and Diego Perotti, while ex-Inter defender Juan Jesus starts at left-back and Roma effectively mirror the Inter formation.
Thomas Vermaelen, Mario Rui and Antonio Rudiger remain long-term injury absentees.
Inter are only missing Marco Andreolli, as Joao Mario has recovered from a back problem to start in midfield.
Joao Miranda is also back following a muscular twinge that ruled him out against Bologna last week.
Antonio Candreva, Ever Banega and Perisic fan out behind Capocannoniere Icardi.
The Nerazzurri haven’t won away to Roma in Serie A since a 4-0 triumph in October 2008, followed by three draws and four defeats.
Inter conceded the first goal in seven of their eight competitive games so far this season.
Roma: Szczesny; Peres, Manolas, Fazio, Jesus; De Rossi, Strootman; Salah, Florenzi, Perotti; Dzeko
Roma bench: Alisson, Lobont, Emerson, Paredes, Seck, Gerson, Iturbe, Totti, El Shaarawy, Nainggolan
Inter: Handanovic; Ansaldi, Miranda, Murillo, Santon; Joao Mario, Medel; Candreva, Banega, Perisic, Icardi
Inter bench: Carrizo, Berni, Ranocchia, D’Ambrosio, Miangue, Felipe Melo, Gnoukouri, Kondogbia, Palacio, Jovetic, Eder, Gabigol