Inter make radical changes for the first home game under Frank de Boer, bringing back Ivan Perisic and Jeison Murillo against Palermo.
It kicks off at San Siro at 17.00 UK time (16.00 GMT), follow the build-up and action on our LIVEBLOG.
De Boer got off to a very rocky start, losing his Serie A debut 2-0 to Chievo and receiving mountains of bad press over his tactics.
Inter make radical changes for the first home game under Frank de Boer, bringing back Ivan Perisic and Jeison Murillo against Palermo.
It kicks off at San Siro at 17.00 UK time (16.00 GMT), follow the build-up and action on our LIVEBLOG.
De Boer got off to a very rocky start, losing his Serie A debut 2-0 to Chievo and receiving mountains of bad press over his tactics.
Unsurprisingly, he shelves the three-man defence and brings Perisic back into the starting XI for a 4-3-3 formation.
Eder is preferred to Antonio Candreva in the trident with Mauro Icardi, while Ever Banega is still adjusting to life in Italian football.
Murillo is back from suspension and Davide Santon steps in for the injured Yuto Nagatomo.
Stevan Jovetic and Caner Erkin are absent ahead of their transfers to Fiorentina and Besiktas respectively.
Palermo started the season with a 1-0 home defeat to Sassuolo and are in the headlines for their attempts to take Mario Balotelli on loan from Liverpool.
Alessandro Diamanti and Bruno Henrique arrive from Guangzhou Evergrande and Corinthians, but are not yet available to play.
Coach Davide Ballardini is without suspended Michel Morganella and Slobodan Rajkovic, while Achraf Lazaar is completing a transfer to Newcastle United.
It’s safe to say Palermo don’t have a good record in this fixture, as they have never beaten Inter away from home in Serie A, managing just eight draws and 20 defeats.
The last 10 editions of this tie have produced a total of 43 goals, so expect fireworks.
Inter: Handanovic; D'Ambrosio, Miranda, Murillo, Santon; Medel, Banega, Kondogbia; Eder, Icardi, Perisic
Inter bench: Carrizo, Berni, Melo, Palacio, Biabiany, Ranocchia, Gnoukouri, Brozovic, Candreva, Yao, Miangue
Palermo: Posavec; Goldaniga, Vitiello, Andelkovic; Rispoli, Hiljemark, Gazzi, Chochev, Aleesami; Quaison; Nestorovski
Palermo bench: Marson, Fulignati, Embalo, Gonzalez, Cionek, Sallai, Balogh, Bouy, Bentivegna, Jajalo, Giuliano, Pezzella