Inter throw Mauro Icardi and Xherdan Shaqiri at a revamped but enthusiastic Juventus in the Derby d’Italia.
It kicks off at 17.00 UK time (16.00 GMT), follow the action as it happens on our LIVEBLOG.
This is usually one of the biggest fixtures of the season, but it feels unusual this time round, not least for its early kick-off time.
Inter throw Mauro Icardi and Xherdan Shaqiri at a revamped but enthusiastic Juventus in the Derby d’Italia.
It kicks off at 17.00 UK time (16.00 GMT), follow the action as it happens on our LIVEBLOG.
This is usually one of the biggest fixtures of the season, but it feels unusual this time round, not least for its early kick-off time.
Roberto Mancini’s Inter have a lot to play for, as they are gambling their last cards to get into the Europa League next season.
Hernanes is suspended after bagging a brace in the 2-1 victory away to Lazio, while Fredy Guarin, Jonathan, Dodo and Hugo Campagnaro are sidelined.
It gives Shaqiri the chance to prove himself after a series of games on the bench.
The man to watch is Icardi, who not only is challenging Carlos Tevez for the Capocannoniere title, but has scored in each of his four career encounters with Juventus in Serie A for a total five goals.
Juve are fresh from their Champions League heroics against Real Madrid and rest numerous stars.
Coach Max Allegri – a former Milan man familiar with San Siro – has to keep players fresh for the Coppa Italia Final with Lazio on May 20 and the Champions League Final against Barcelona on June 6.
Martin Caceres is the only injury absentee, but Juve are resting the likes of Carlos Tevez, Gigi Buffon, Arturo Vidal, Andrea Pirlo and Giorgio Chiellini.
Inter have won only one of their last nine Serie A meetings with Juve, drawing three and losing five.
The last Bianconeri top flight defeat at San Siro was in April 2010, followed by two victories and two stalemates.
Inter: Handanovic; D'Ambrosio, Ranocchia, Vidic, Jesus; Brozovic, Medel, Kovacic; Shaqiri; Palacio, Icardi
Inter bench: Carrizo, Andreolli, Podolski, Kuzmanovic, Obi, Santon, Felipe, Gnoukouri, Puscas, Nagatomo, Dimarco, Bonazzoli
Juventus: Storari; Lichtsteiner, Barzagli, Bonucci, Padoin; Romulo, Marchisio, Sturaro; Pereyra; Matri, Morata
Juventus bench: Moedim, Audero, Ogbonna, Pogba, Pepe, Coman, Llorente, De Ceglie, Asamoah, Marrone
Ref: Doveri