Inter drop Mauro Icardi and bring Rodrigo Palacio back into the line-up as Diego Perotti returns for Genoa.
It kicks off at 19.45 GMT, follow the build-up and action on our LIVEBLOG.
The Nerazzurri suffered only their second defeat of the season last week, a 2-1 at Napoli sending the Partenopei top of the table.
Roberto Mancini’s men have the opportunity to recapture the leadership for a night.
Inter drop Mauro Icardi and bring Rodrigo Palacio back into the line-up as Diego Perotti returns for Genoa.
It kicks off at 19.45 GMT, follow the build-up and action on our LIVEBLOG.
The Nerazzurri suffered only their second defeat of the season last week, a 2-1 at Napoli sending the Partenopei top of the table.
Roberto Mancini’s men have the opportunity to recapture the leadership for a night.
Geoffrey Kondogbia and Davide Santon are still injured with Yuto Nagatomo suspended following his red card at the Stadio San Paolo.
Felipe Melo comes back into the fold, but Icardi is dropped after Mancini criticised him for not working enough for the team.
Instead, Rodrigo Palacio is the centre-forward in a new 4-4-2 system supported by Stevan Jovetic, Adem Ljajic and Jonathan Biabiany.
Genoa are fresh from a surprise 2-1 home defeat to Carpi, although had to play almost the entire match with 10 men.
Leonardo Pavoletti begins his three-match ban for that moment of madness, joining Alassane Tambe, Giovanni Marchese, Blerim Dzemaili, Panagiotis Tachtsidis and Ezequiel Munoz on the absentee list.
Star forward Diego Perotti returns from suspension to bolster the attack with Inter loaner Diego Laxalt and the pacey Darko Lazovic.
Nicolas Burdisso and of course Coach Gian Piero Gasperini are also ex-Inter men, while Goran Pandev is on the bench.
Inter: Handanovic; D'Ambrosio, Miranda, Murillo, Telles; Biabiany, Medel, Felipe Melo, Ljajic; Jovetic, Palacio
Inter bench: Carrizo, Berni, Juan Jesus, Dodò, Icardi, Guarin, Montoya, Ranocchia, Gnoukouri, Perisic, Brozovic, Manaj
Genoa: Perin; Izzo, Burdisso, Ansaldi; Figueiras, Rincon, Tino Costa, Laxalt; Lazovic, Perotti, Gakpé
Genoa bench: Lamanna, Ujkani, De Maio, Capel, Ntcham, Pandev, Ricozzi, Sandro, Cissokho, Ghiglione