Inter hope Mauro Icardi can break his Serie A duck with Ivan Perisic and Radja Nainggolan, as Fiorentina start Kevin Mirallas, Giovanni Simeone and Federico Chiesa.
It kicks off at San Siro at 20.00 UK time (19.00 GMT).
Click here to follow the build-up and action as it happens on the LIVEBLOG.
Inter hope Mauro Icardi can break his Serie A duck with Ivan Perisic and Radja Nainggolan, as Fiorentina start Kevin Mirallas, Giovanni Simeone and Federico Chiesa.
It kicks off at San Siro at 20.00 UK time (19.00 GMT).
Click here to follow the build-up and action as it happens on the LIVEBLOG.
The Nerazzurri have accustomed their fans to drama lately, losing to Sassuolo and Parma, yet fighting back to beat Tottenham Hotspur in the Champions League and securing a last-gasp victory over Sampdoria.
Icardi was Capocannoniere last term alongside Lazio’s Ciro Immobile, but is yet to score in Serie A this season, although he did fire in a stunning volley against Spurs.
He is supported by Perisic, Nainggolan and Antonio Candreva, who gets the nod rather than Matteo Politano.
Marcelo Brozovic, scorer of the decider against Sampdoria, is in midfield with Matias Vecino.
Joao Miranda is out of the squad due to an inflammation of the left ankle, but Stefan de Vrij makes his 100th Serie A appearance.
Fiorentina are also flying high with a very impressive campaign so far, losing only one game very narrowly to Napoli.
Former Everton player Kevin Mirallas gets his first Serie A start after two substitute appearances, but the star men are Chiesa and Simeone, the sons of great players who are making names for themselves.
Edimilson Fernandes pulls the midfield strings rather than Gerson.
Luciano Spalletti was meant to sit out a one-match ban for over-celebrating in what the VAR officials perceived to be a dig at them, but he won his appeal and will be on the bench.
Entertainment ought to be guaranteed, because there have been 28 goals in the last six Serie A meetings between these sides, an average of 4.7 per game.
Fiorentina lost 16 of their last 19 trips to San Siro, winning the other three.
Inter: Handanovic; D'Ambrosio, De Vrij, Skriniar, Asamoah; Vecino, Brozovic; Candreva, Nainggolan, Perisic; Icardi
Inter bench: Padelli, Gagliardini, Lautaro Martinez, Keita, Ranocchia, Joao Mario, Politano, Borja Valero, Dalbert
Fiorentina: Lafont; Milenkovic, Pezzella, Hugo, Biraghi; Benassi, Veretout, Edimilson Fernandes; Chiesa, Simeone, Mirallas
Fiorentina bench: Dragowski, Laurini, Ceccherini, Norgaard, Eysseric, Gerson, Pjaca, Dabo, Hancko, Vlahovic, Diks, Thereau