Genoa are eager to cause a huge upset with Mattia Destro and Kevin Strootman, taking revenge for a 6-0 defeat against a Napoli side stretched thin.
It kicks off at the Stadio Luigi Ferraris at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Genoa are eager to cause a huge upset with Mattia Destro and Kevin Strootman, taking revenge for a 6-0 defeat against a Napoli side stretched thin.
It kicks off at the Stadio Luigi Ferraris at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Grifone are a team transformed since Davide Ballardini returned to the bench, keeping four clean sheets in seven matches and averaging two points per game.
They also bolstered their ranks with Kevin Strootman in the January transfer window and kept hold of Gianluca Scamacca, but Goran Pandev partners Destro because Eldor Shomurodov is not fully fit.
Davide Biraschi and Cristian Zapata are also out of action.
Napoli have several problems this evening, as they are between Coppa Italia semi-finals against Atalanta with the first leg ending 0-0, while Dries Mertens is injured.
Kalidou Koulibaly and Faouzi Ghoulam were diagnosed with COVID-19 this week, although Fabian Ruiz recovered after almost three weeks.
Lorenzo Insigne has a knock to his calf, so is rested for Matteo Politano.
Genoa: Perin; Goldaniga, Radovanovic, Criscito; Zappacosta, Zajc, Badelj, Strootman, Czyborra; Destro, Pandev
Napoli: Ospina; Di Lorenzo, Manolas, Maksimovic, Mario Rui; Demme, Elmas; Politano, Zielinski, Lozano; Petagna
Ref: Manganiello