Juventus mark a Gigi Buffon milestone and Gian Piero Gasperini surprises in a tricky trip to Genoa.
It kicks off at 19.45 GMT, click here for a match preview.
Last season this game was decided by a last-gasp Andrea Pirlo free kick to break hearts at Marassi, but the veteran midfielder is rested with Claudio Marchisio taking on his deep-lying playmaker position.
Juventus mark a Gigi Buffon milestone and Gian Piero Gasperini surprises in a tricky trip to Genoa.
It kicks off at 19.45 GMT, click here for a match preview.
Last season this game was decided by a last-gasp Andrea Pirlo free kick to break hearts at Marassi, but the veteran midfielder is rested with Claudio Marchisio taking on his deep-lying playmaker position.
Juve are three points clear at the top of the table, but confidence is still shaky after two consecutive Champions League defeats and a 1-1 draw at Sassuolo in their last Serie A away game.
Andrea Barzagli, Patrice Evra, Martin Caceres and Simone Pepe are out of action.
Buffon will be wearing a special captain’s armband to mark his 500th appearance in a Juventus jersey and does so against the club he supported as a child.
Genoa miss Ioannis Fetfatzidis and Tomas Rincon, but fought back on Sunday for a 2-1 victory away to 10-man Chievo.
Alessandro Matri was on target, but is surprisingly benched in favour of Mauricio Pinilla against his former club and the Coach he worked with at both Cagliari and Milan.
It was Massimiliano Allegri who tempted Matri away from Turin to join Milan, though the striker has been on a series of disappointing loan spells ever since.
Stefano Sturaro failed a fitness test, a disappointment as Juventus bought him in July and immediately handed the midfielder back to Genoa on loan.
A huge shock from Gasperini is picking 17-year-old Rolando Mandragora from the start in his Serie A debut.
The pitch at the Stadio Luigi Ferraris is still in very poor condition after recent flash floods in the city that killed one man near the stadium and left many homeless.
Genoa: Perin; Marchese, De Maio, Burdisso, Rosi, Mandragora, Greco, Antonelli, Bertolacci, Pinilla, Perotti
Genoa bench: Kucka, Mussis, Lestienne, Antonini, Sommariva, Falque, Matri, Lamanna, Edenilson, Roncaglia, Izzo
Juventus: Buffon; Ogbonna, Bonucci, Chiellini; Lichtsteiner, Vidal, Marchisio, Pogba, Asamoah; Tevez, Llorente
Juventus bench: Storari, Rubinho, Romulo, Marrone, Padoin, Pirlo, Mattiello, Pereyra, Morata, Coman, Giovinco