Sassuolo aim to continue their Europa League adventure with a trip to Genk, but are dealing with a massive injury crisis.
It kicks off at 20.05 UK time (19.05 GMT), follow all four Italian competitors in the LIVEBLOG.
The Neroverdi got through several play-offs and won their group opener convincingly, beating Athletic Bilbao 3-0.
Now they face a tricky trip to Belgium and are doing it without half their star players.
Sassuolo aim to continue their Europa League adventure with a trip to Genk, but are dealing with a massive injury crisis.
It kicks off at 20.05 UK time (19.05 GMT), follow all four Italian competitors in the LIVEBLOG.
The Neroverdi got through several play-offs and won their group opener convincingly, beating Athletic Bilbao 3-0.
Now they face a tricky trip to Belgium and are doing it without half their star players.
Among those ruled out are Domenico Berardi, Alfred Duncan, Paolo Cannavaro, Alessandro Matri, Alessandro Gazzola, Luca Antei and Simone Missiroli.
Gregoire Defrel is on fire at the moment and leads the trident attack with Matteo Politano and Stefano Ricci.
Genk are forced to do without Uronen and Wouters in defence and their recent form has been terrible.
They are without a win since August 28, losing in Vienna for the Europa League opener and suffering three consecutive defeats domestically.
The danger man is Leon Bailey, the 19-year-old Jamaican left-sided winger who is back from injury.
Genk: Bizot; Walsh, Brabec, Colley, Nastic; Pozuelo, Ndidi, Susic; Bailey, Karelis, Buffel
Genk bench: Jackers, Castagne, Dewaest, Kumordzi, Heynen, Trossard, Samatta
Sassuolo: Consigli; Lirola, Letschert, Acerbi, Peluso; Biondini, Magnanelli, Pellegrini; Ricci, Defrel, Politano
Sassuolo bench: Pegolo, Pomini, Adjapong, Mazzitelli, Franchini, Caputo, Ragusa