Riccardo Saponara and Massimo Maccarone host Franco Vazquez in a new centre-forward role in Empoli v Palermo.
It kicks off at 17.00 GMT, click here for a match preview.
Although Empoli had a very strong start to the season, they have plummeted down the standings thanks to just five draws in the last 10 rounds.
Palermo are hovering only one point above the drop zone thanks to a chaotic campaign that saw them change Coach eight times since November.
Riccardo Saponara and Massimo Maccarone host Franco Vazquez in a new centre-forward role in Empoli v Palermo.
It kicks off at 17.00 GMT, click here for a match preview.
Although Empoli had a very strong start to the season, they have plummeted down the standings thanks to just five draws in the last 10 rounds.
Palermo are hovering only one point above the drop zone thanks to a chaotic campaign that saw them change Coach eight times since November.
Walter Novellino made his debut in last week’s slender defeat to Napoli, but this is the type of match where he’ll need to pick up a result to avoid relegation.
Ivaylo Chochev is suspended with Edoardo Goldaniga injured.
Vazquez is surprisingly used in a new centre-forward role with Robin Quaison, Gaston Brugman and Aleksandar Trajkovski in support.
This means veteran striker Alberto Gilardino is sent to the bench.
Empoli have almost a full squad to choose from, as Lorenzo Tonelli is back from his three-match ban, so only Uros Cosic misses out.
When these sides met in November, Empoli emerged 1-0 winners in Sicily with a Saponara free kick.
Empoli: Skorupski; Laurini, Costa, Tonelli, Mario Rui; Zielinski, Paredes, Croce; Saponara; Pucciarelli, Maccarone
Empoli bench: Pugliesi, Pelagotti, Zambelli, Bittante, Mchedlidze, Maiello, Diousse, Piu, Camporese, Krunic, Ariaudo, Buchel
Palermo: Sorrentino; Struna, Gonzalez, Andelkovic, Pezzella; Hiljemark, Jajalo, Hiljemark, Quaison, Brugman, Trajkovski; Vazquez
Palermo bench: Posavec, Vitiello, Rispoli, Lazaar, Bentivegna, Gilardino, Cionek, Balogh, Cristante, Maresca, Morganella, Djurdjevic