Sergej Milinkovic-Savic and Dusan Basta have not recovered in time for Lazio as they take on rivals Roma.
It kicks off on Sunday at 14.00 UK time (13.00 GMT), click here for a match preview.
Stefano Pioli has a decimated squad going into the Derby della Capitale.
Senad Lulic is suspended, while Milinkovic-Savic and Basta have not been able to recover in time.
Also absent are Stefan Radu, Ricardo Kishna, Abdoullay Konko and Stefan de Vrij.
Sergej Milinkovic-Savic and Dusan Basta have not recovered in time for Lazio as they take on rivals Roma.
It kicks off on Sunday at 14.00 UK time (13.00 GMT), click here for a match preview.
Stefano Pioli has a decimated squad going into the Derby della Capitale.
Senad Lulic is suspended, while Milinkovic-Savic and Basta have not been able to recover in time.
Also absent are Stefan Radu, Ricardo Kishna, Abdoullay Konko and Stefan de Vrij.
Lazio squad for Roma: Marchetti, Guerrieri, Matosevic; Bisevac, Braafheid, Gentiletti, Hoedt, Mauricio, Patric; Biglia, Candreva, Cataldi, Felipe Anderson, Mauri, Onazi, Parolo; Djordjevic, Keita, Klose, Matri