Lazio coach Maurizio Sarri seems set to rotate the squad, giving Vedat Muriqi and Mattia Zaccagni a place in the attack, while Alessandro Zanoli could start for Napoli in England.
The match in Istanbul between Galatasaray and Lazio kicks off at 17.45 UK time, when Muriqi gets a chance to shine against a Super Lig side.
Sarri is expected to make many changes from the team that lost to Milan last time with Manuel Lazzari at right-back and Patric favoured over Luiz Felipe.
Radu seems set to start, to give Elseid Hysaj a chance to rest, while Sergej Milinkovic-Savic needs to work overtime in the middle.
In attack, Muriqi should replace Ciro Immobile, with Felipe Anderson and Zaccagni completing the trident.
Napoli travel to the King Power Stadium for their opening game at 20.00 and the injury list at the Partenopei forces Luciano Spalletti to count on many of the same players.
The restrictions in the UK could have given David Ospina, Victor Osimhen and Kalidou Koulibaly problems after their respective international duties with Colombia, Nigeria and Senegal.
But the rules have been modified and gives the three stars green light to play against the Foxes.
Zanoli seems set for a place in the line-up, fighting with Kevin Malcuit, as Giovanni Di Lorenzo could start at left-back.
Zambo Anguissa is confirmed in the middle after a great start against Juventus, while Piotr Zielinski should start as an attacking midfielder, with Hirving Lozano and Lorenzo Insigne completing the trident behind Osimhen.
Probable line-ups for Galatasaray vs. Lazio (17.45 UK time)
Galatasaray (4-1-4-1): Muslera; Yedlin, Luyindama, Marcao, van Aanholt; Kutlu; Akturkoglu, Antalyali, Morutan, Cicaldau; Dervisoglu
Lazio (4-3-3): Strakosha; Lazzari, Patric, Acerbi, Radu; Milinkovic Savic, Escalante, Basic; Felipe Anderson, Muriqi, Zaccagni
Probable line-ups for Leicester vs. Napoli (20.00 UK time)
Leicester (4-2-3-1): Schmeichel; Castagne, Soyuncu, Vestergaard, Bertrand; Tielemans, Ndidi; Albrighton, Maddison, Barnes; Vardy
Napoli (4-2-3-1): Ospina; Zanoli, Rrahmani, Koulibaly, Di Lorenzo; Anguissa, Fabian Ruiz; Lozano, Zielinski, Insigne; Osimhen